lymphocyte homing meaning in English

淋巴细胞归巢,淋巴细胞寻靶

Chemotaxis mediated by chemokine receptors , such as cxcr4 , play a key role in lymphocyte homing and hematopoiesis as well as in breast cancer metastasis . we have previously demonstrated that ? - arrestin2 functions to attenuate cxcr4 - meidated g protein activation and to enhance cxcr4 internalization . here we further show that expression of ( - arrestin2 in both hela and hek293 cells significantly enhanced the chemotactic efficacy of stromal - cell derived factor 1 ( ( sdf - 1 ( ) , the specific agonist of cxcr4
- arrestin2是趋化因子受体的一种重要的调节蛋白，本研究工作发现在hek - 293或hela细胞中升高- arrestin2的表达水平会显著增强cxcr4介导的趋化作用，反之当- arrestin2的表达被它的反义核苷酸或rnai所抑制， cxcr4介导的趋化作用则被明显抑制。